Redox-Based Transcriptional Regulation in Prokaryotes: Revisiting Model Mechanisms
نویسندگان
چکیده
منابع مشابه
Thiol-based redox switches in prokaryotes.
Bacteria encounter reactive oxygen species (ROS) as a consequence of the aerobic life or as an oxidative burst of activated neutrophils during infections. In addition, bacteria are exposed to other redox-active compounds, including hypochloric acid (HOCl) and reactive electrophilic species (RES) such as quinones and aldehydes. These reactive species often target the thiol groups of cysteines in...
متن کاملRedox-dependent transcriptional regulation.
Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response to oxidative stress, cells activate expression of a number of genes, including those required for the detoxification of reactive molecules as well as for the repair and maintenance of cellular homeostasis. In many ...
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Transcriptional regulation contributes to the maintenance of pluripotency, self-renewal and differentiation in embryonic cells and in stem cells. Therefore, control of gene expression at the level of transcription is crucial for embryonic development, as well as for organogenesis, functional adaptation, and regeneration in adult tissues and organs. In the past, most work has focused on how tran...
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For bacteria, cysteine thiol groups in proteins are commonly used as thiol-based switches for redox sensing to activate specific detoxification pathways and restore the redox balance. Among the known thiol-based regulatory systems, the MarR/DUF24 family regulators have been reported to sense and respond to reactive electrophilic species, including diamide, quinones, and aldehydes, with high spe...
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PERSPECTIVE AND SUMMARY ................................................................ 1051 YEAST PROMOTER ELEMENTS ................................................................ 1052 SPECIFIC DNA-BINDING PROTEINS .......................................................... 1054 TRANSCRIPTIONAL ACTIVATION ............................................................ 1059 REGULATION ..............
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2019
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2017.7442